What question did this study set out to answer?

To evaluate alterations in peripheral blood inflammatory markers and cytokines, especially interleukin-6 (IL-6), to determine their utility for monitoring severe COVID-19 cases.

March 6, 2020Open Access

The potential role of IL-6 in monitoring severe case of coronavirus disease 2019

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To evaluate alterations in peripheral blood inflammatory markers and cytokines, especially interleukin-6 (IL-6), to determine their utility for monitoring severe COVID-19 cases.
Collected and analyzed clinical, laboratory, and chest computed tomography (CT) data from patients diagnosed with severe and nonsevere COVID-19 at a single institution.
Assessed demographic factors, clinical manifestations, peripheral blood cells, and inflammatory cytokines across 69 severe COVID-19 patients, including pre- and post-treatment IL-6 levels in 30 patients.
Severe COVID-19 cases exhibited marked lymphocytopenia and elevated baseline levels of IL-6, C-reactive protein (CRP), lactate dehydrogenase (LDH), ferritin, and D-dimer, with 60.87% presenting bilateral pulmonary involvement on CT imaging.
Baseline IL-6 levels correlated positively with maximal body temperature, chest CT abnormalities, and elevations in CRP, LDH, ferritin, and D-dimer.
Among 30 severe patients reassessed after therapy, 25 showed significant IL-6 reductions alongside CT improvements, whereas 3 patients with increased IL-6 experienced disease exacerbation.

Authors

TLTao LiuGansu Provincial Hospital JZJieying ZhangUnion Hospital YYYuhui YangJinan University

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Implication

Observational cohort study reveals that dynamic interleukin-6 levels track disease severity in severe COVID-19 patients, indicating its utility for clinical monitoring and treatment response.

Cite This Study

Liu et al. (2020) studied this question.

synapsesocial.com/papers/6a98fd40ee2e02d2bfe109fa https://doi.org/10.1101/2020.03.01.20029769

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Implication

Observational cohort study reveals that dynamic interleukin-6 levels track disease severity in severe COVID-19 patients, indicating its utility for clinical monitoring and treatment response.

The potential role of IL-6 in monitoring severe case of coronavirus disease 2019

Key Points

Discussion

Implication

Cite This Study

The potential role of IL-6 in monitoring severe case of coronavirus disease 2019

Key Points

Discussion

Implication

Cite This Study

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