Why the study?
Does intravenous salbutamol supplemented with oral salbutamol improve the delay achieved in premature labour compared to intravenous salbutamol alone?
Does intravenous salbutamol supplemented with oral salbutamol improve the delay achieved in premature labour compared to intravenous salbutamol alone?
Intravenous salbutamol effectively inhibits uterine contractions in premature labor, but the addition of oral salbutamol does not statistically significantly increase the delay of labor.
IV salbutamol inhibits contractions reliably; oral addition leaves open any further delay benefit in preterm labor.
Salbutamol was administered intravenously to 14 patients in premature labour. Inhibition of uterine contractions occurred on 22 out of 23 occasions. The mean increase in maternal and fetal heart rate and blood pressure were within clinically acceptable limits but there were wide individual variations. The mean delay achieved when the intravenous regime was supplemented with oral salbutamol was greater than that achieved by intravenous salbutamol alone, but the difference was not statistically significant.
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Dawson et al. (1977) studied this question.
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