On the Metabolism of Prostaglandin F2α in Female Subjects
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Implication
Metabolic investigation reveals two primary metabolites of intravenous prostaglandin F2α in female subjects, indicating a major degradation pathway for systemic clearance.
Key Points
- To isolate and characterize the primary metabolites of prostaglandin F2α following intravenous administration in human females.
- Administered prostaglandin F2α intravenously to female subjects and isolated the excreted chemical metabolites.
- Determined metabolite structures using gas chromatography, mass spectrometry, infrared spectrometry, and nuclear magnetic resonance spectrometry.
- Confirmed the δ-lactone structure by alkaline hydrolysis to a dioic acid and mass spectrometry analysis following borodeuteride reduction.
- Identified 5α,7α-dihydroxy-11-ketotetranorprosta-1,16-dioic acid and its δ-lactone as the two primary metabolic products of prostaglandin F2α.
- Established the chemical transformation pathway showing the metabolic conversion of prostaglandin F2α into 5α,7α-dihydroxy-11-ketotetranorprosta-1,16-dioic acid.
Cite This Study
Granström et al. (1971) studied this question.