Key result
Peroperative administration of 2 gm intravenous magnesium significantly reduced the incidence of postoperative arrhythmias (33.3% vs 63.3%) compared to no magnesium in patients undergoing conventional CABG surgery.
Why the study?
Does intravenous magnesium reduce the incidence of per and postoperative arrhythmias in patients undergoing conventional CABG surgery?
RCT (n=60)
Randomly selected
No
Does intravenous magnesium reduce the incidence of per and postoperative arrhythmias in patients undergoing conventional CABG surgery?
Absolute Event Rate: 33.33% vs 63.33%
p-value: p=<0.05
Peroperative administration of intravenous magnesium significantly reduces the incidence of arrhythmias during and after conventional CABG surgery.
Supports peroperative magnesium in CABG protocols; extends randomized evidence for arrhythmia prevention in cardiac surgery.
Introduction: Arrhythmias are not uncommon after Coronary Artery Bypass Graft (CABG) surgery. There is increasing evidence that Magnesium, the important intracellular cation plays a crucial role in preventing and terminating cardiac arrhythmias. Objectives: The aim of this study was to establish the role of peroperative use of intravenous Magnesium in reducing the incidence of per and postoperative arrhythmias in CABG surgery. Materials and methods: A total sixty (Group-I 30 and Group-II 30) patients of both sexes and different ages undergoing conventional CABG surgery under general anesthesia in CMH Dhaka from January 2009 to December 2011 were selected randomly. After induction, Group-I received 2 gm of Magnesium in 100 ml normal saline intravenously over a period of 30 minutes and Group-II received no Magnesium. Parameters recorded per and postoperatively were- aortic cross clamp time, Cardio Pulmonary Bypass (CPB) time, total surgery time, Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and blood sample were collected on arrival to Cardiac Intensive Care Unit (CICU) and after 6, 12, and 24 hours. Results were expressed as mean ± SD (Standard Deviation) or in frequencies (percentage) as applicable. The results were analyzed by Students t test. Results: Magnesium levels were significantly (p<0.05) low in Group-II patients than that of Group-I. In Group-II patients, the fluctuations of HR, SBP and DBP were significantly (p<0.05) more than that of Group-I. In Group-I patients incidence of arrhythmias were significantly (p<0.05) less than that of Group-II. Conclusion: Low serum Magnesium levels are a frequent finding after conventional CABG surgery. This acute loss of Magnesium has been suggested as an etiology of many per and postoperative arrhythmias. This study revealed that peroperative administration of Magnesium provided a significant reduction in arrhythmias per and postoperatively. DOI: http://dx.doi.org/10.3329/jafmc.v9i1.18739 Journal of Armed Forces Medical College Bangladesh Vol.9(1) 2013: 105-114
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Ahsan et al. (2014) conducted an RCT in Coronary Artery Disease requiring CABG (n=60). Intravenous Magnesium vs. No Magnesium was evaluated on Incidence of postoperative arrhythmias in the Cardiac Intensive Care Unit (CICU) (p=<0.05). Peroperative administration of 2 gm intravenous magnesium significantly reduced the incidence of postoperative arrhythmias (33.3% vs 63.3%) compared to no magnesium in patients undergoing conventional CABG surgery.
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