Key result
The rs2824292 polymorphism at chromosome 21q21 was significantly associated with an increased risk of ventricular fibrillation during a first acute myocardial infarction (OR 1.78).
Why the study?
Is the genetic variant at chromosome 21q21 (rs2824292) associated with an increased risk of ventricular fibrillation during a first ST-elevation myocardial infarction?
Case-Control (n=972)
Yes
Is the genetic variant at chromosome 21q21 (rs2824292) associated with an increased risk of ventricular fibrillation during a first ST-elevation myocardial infarction?
Odds Ratio: 1.78 (95% CI 1.47–2.13)
p-value: p=3.3x10^-10
A novel genetic locus at chromosome 21q21 (rs2824292) is significantly associated with susceptibility to ventricular fibrillation during a first ST-elevation myocardial infarction.
May support genetic VF risk research in STEMI; hypothesis-generating and should not yet change practice.
Sudden cardiac death from ventricular fibrillation during myocardial infarction is a leading cause of total and cardiovascular mortality. This multifactorial, complex condition clusters in families, suggesting a substantial genetic cause. We carried out a genomewide association study (GWAS) for sudden cardiac death, in the AGNES (Arrhythmia Genetics in the Netherlands) population, consisting of patients with (cases) and without (controls) ventricular fibrillation during a first ST-elevation myocardial infarction. The most significant association was found at chromosome 21q21 (rs2824292; odds ratio = 1.78, 95% CI 1.47-2.13, P = 3.3 × 10(-10)), 98 kb proximal of the CXADR gene, encoding the Coxsackie and adenovirus receptor. This locus has not previously been implicated in arrhythmia susceptibility. Further research on the mechanism of this locus will ultimately provide novel insight into arrhythmia mechanisms in this condition.
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Marsman et al. (2011) conducted a case-control in Ventricular fibrillation during first ST-elevation myocardial infarction (n=972). rs2824292 polymorphism at chromosome 21q21 vs. Absence of the risk allele was evaluated on Ventricular fibrillation during a first ST-elevation myocardial infarction (OR 1.78, 95% CI 1.47-2.13, p=3.3x10^-10). The rs2824292 polymorphism at chromosome 21q21 was significantly associated with an increased risk of ventricular fibrillation during a first acute myocardial infarction (OR 1.78).
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