Key result
An ESR1 variant is linked to ~43% higher sudden cardiac arrest risk in CAD.
Why the study?
Epidemiologic evidence suggests a heritable component to risk for sudden cardiac arrest independent of myocardial infarction risk, but previous candidate gene studies yielded conflicting results.
Are specific genetic loci associated with sudden cardiac arrest in patients with coronary artery disease?
Population
89 patients with coronary artery disease and sudden cardiac arrest and 520 healthy controls
Comparison
Patients with sudden cardiac arrest vs healthy controls
Design
Genome-wide association study case-control design
Authors
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May inform SCA risk models in CAD; hypothesis-generating and requires validation before clinical use.
Case-Control (n=609)
Yes
Are specific genetic loci associated with sudden cardiac arrest in patients with coronary artery disease?
Odds Ratio: 1.43 (95% CI 1.277–1.596)
p-value: p=2.62 × 10^-8
This genome-wide association study identified 11 gene associations linked to sudden cardiac arrest due to ventricular tachycardia or fibrillation in patients with coronary artery disease.
Aouizerat et al. (2011) conducted a case-control in Sudden cardiac arrest in coronary artery disease (n=609). Genetic variation (SNPs) vs. Absence of risk alleles / Healthy controls was evaluated on Sudden cardiac arrest due to ventricular tachycardia or ventricular fibrillation (OR 1.43, 95% CI 1.277-1.596, p=2.62 × 10^-8). Fourteen single nucleotide polymorphisms, including a variant in ESR1 (OR 1.43), were significantly associated with sudden cardiac arrest in patients with coronary artery disease.
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