Why the study?
Is plasma urotensin II a useful biomarker for the diagnosis of systolic heart failure compared to N-BNP?
Population
126 patients with heart failure (left ventricular systolic dysfunction) and 220 age- and sex-matched controls
Comparison
Measurement of plasma urotensin II (UTN) vs Measurement of N-terminal pro-brain natriuretic…
Design
Case-control
Authors
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UTN may complement N-BNP for early HF detection; leaves open its diagnostic role pending prospective validation.
Is plasma urotensin II a useful biomarker for the diagnosis of systolic heart failure compared to N-BNP?
Plasma urotensin II is elevated in systolic heart failure irrespective of age, sex, or NYHA class, suggesting it may be a useful alternative diagnostic biomarker to N-BNP, particularly in early-stage (NYHA I) disease.
Ng et al. (2002) studied this question.
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