The synthesis and purification of L-tyrosylglycylglycyl-L-phenylalanyl-L-methione (methionine5-enkephalin) and L-tyrosylglycylglycyl-L-phenylalanyl-L-leucine (leucine5-enkephalin) are described. These synthetic peptides were identical in both physical and biological characteristics with the constituents of enkephalin, a material isolated from porcine brain with potent receptor-mediated opiate agonist activity.
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Bower et al. (1976) studied this question.