Key result
Bioelectronic medicine, particularly vagus nerve stimulation, represents a promising conceptual innovation for the targeted treatment of chronic inflammatory diseases by modulating neural reflex circuits.
Why the study?
Does bioelectronic medicine (vagus nerve stimulation) ameliorate chronic inflammatory diseases?
Does bioelectronic medicine (vagus nerve stimulation) ameliorate chronic inflammatory diseases?
Bioelectronic medicine, specifically vagus nerve stimulation, offers a promising new therapeutic avenue for chronic inflammatory diseases by modulating the inflammatory reflex.
Answers are grounded in this paper and cite their sources.
Not ready for clinical use in inflammatory diseases; leaves open efficacy and safety pending randomized trials.
Recent discoveries in neuroscience and immunology have revealed that stimulation of specific neural circuits can ameliorate certain experimental inflammatory diseases. Accumulating evidence on a prototypical reflex circuit that includes the vagus nerve, termed the “inflammatory reflex,” has spawned clinical trials using implanted vagus nerve stimulators to treat patients with chronic inflammatory diseases. Modulation of neural reflex activity potentially represents a groundbreaking advance in treatment options for chronic inflammation, but our understanding of the involved components and signals is still incomplete. Here, the experimental basis for use of bioelectronic medicine in treatment of inflammatory disease and future challenges in this rapidly evolving field are reviewed and discussed.
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Peder S. Olofsson (2014) conducted a review in Inflammatory diseases. Vagus nerve stimulation (Bioelectronic medicine) was evaluated. Bioelectronic medicine, particularly vagus nerve stimulation, represents a promising conceptual innovation for the targeted treatment of chronic inflammatory diseases by modulating neural reflex circuits.
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