Key result
Epileptic status in Wistar rats leads to a long-lasting disturbance of autonomic regulation of the heart, shifting towards sympathetic tonus at 5 days and increasing the risk of arrhythmias.
Why the study?
To investigate postictal changes in autonomic regulation of heart rhythm and functional capabilities across different periods after status epilepticus, and to evaluate the risk of life-threatening arrhythmias.
Does status epilepticus alter autonomic regulation of the heart and increase the risk of arrhythmias in Wistar rats?
Does status epilepticus alter autonomic regulation of the heart and increase the risk of arrhythmias in Wistar rats?
Status epilepticus in a rat model induces prolonged autonomic dysregulation of the heart, increasing the risk of life-threatening arrhythmias.
Should not alter status epilepticus management; hypothesis-generating for autonomic shifts as human arrhythmia predictors.
AIM: To study the postictal changes in the autonomic regulation of the heart rhythm and its functional capabilities in different periods after epistatus and to assess the risk of life-threatening arrhythmias. MATERIAL AND METHODS: The study was conducted on Wistar rats after epileptic status (ES). Telemonitoring of EEG and ECG was performed in the online mode using the system of the company 'ADInstruments'. Functional stress test with dobutamine was used. RESULTS: ES leads to a long-lasting disturbance of autonomic regulation (AR) of the heart and reduces its functional capabilities. The heart's AR balance is shifted towards sympathetic tonus 5 days after ES. This increases the predictors of life-threatening arrhythmias. The decrease in SWD activity increases the activity of parasympathetic tonus 10 days after ES. However, this is due to the tension of regulation mechanisms and the risk of life-threatening arrhythmias. CONCLUSION: The high degree of seizure activity of the brain in the ES predetermines prolonged postictal disorders of the AR heart, which reduce its functional capabilities and increase the risk of life-threatening arrhythmias.
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Мамалыга et al. (2019) studied Epileptic status. Epileptic status was evaluated on Autonomic regulation of the heart rhythm and its functional capabilities. Epileptic status in Wistar rats leads to a long-lasting disturbance of autonomic regulation of the heart, shifting towards sympathetic tonus at 5 days and increasing the risk of arrhythmias.
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