Key result
Regional nerve blocks reduced the incidence of postoperative delirium (OR 0.44; 95% CI 0.30-0.64; p<0.001) and cognitive dysfunction (OR 0.43; 95% CI 0.24-0.76) after thoracic surgery.
Why the study?
This study aimed to determine the exact effect of regional nerve blocks on postoperative cognitive dysfunction and postoperative delirium in adult patients undergoing thoracic surgery.
Do regional nerve blocks reduce the incidence of postoperative delirium or cognitive dysfunction in adult patients undergoing thoracic surgery?
Meta-Analysis (n=1,010)
Do regional nerve blocks reduce the incidence of postoperative delirium or cognitive dysfunction in adult patients undergoing thoracic surgery?
Regional nerve blocks significantly mitigate the occurrence of postoperative delirium, cognitive dysfunction, and pain in adult patients following thoracic surgery.
Answers are grounded in this paper and cite their sources.
Supports nerve block integration into thoracic surgery protocols; confirms cognitive protection in Level 1 meta-analysis.
Regional nerve blocks (NBs) mitigate the occurrence of postoperative cognitive dysfunction (POCD) and postoperative delirium (POD) in adult patients undergoing thoracic surgery. This study aimed to determine the exact effect of NBs on POCD and POD. Electronic databases, including PubMed, EMBASE, CINAHL, Scopus, and Web of Science, were searched for studies. The primary outcome was the incidence of POD or POCD. The secondary outcome was pain scores assessed 24 and 48 h postoperatively. We calculated the log odds ratio (LOR) and standardized mean difference (SMD) with 95% confidence intervals (CIs). The LOR was converted to an odds ratio (OR). In the analysis of 1010 patients from seven randomized controlled trials, POD and POCD rates were 14.1% and 16.7%, respectively, in the NB group, and higher, at 27.3% and 35.2%, in the control group. NBs reduced the incidence of POD (OR, 0.44; 95%CI 0.30 to 0.64; p < 0.001; I2 = 0.00%) and POCD (OR, 0.43; 95%CI 0.24 to 0.76; p < 0.001; I2 = 0.00%). NBs reduced pain scores at 24 h (SMD, −2.60; 95%CI −3.90 to −1.30, p < 0.001; I2 = 97.68%) and 48 h (SMD, −1.80; 95%CI −3.18 to −0.41, p = 0.01; I2 = 98.14%) postoperatively. NBs mitigated the occurrence of POD and POCD in adult patients after thoracic surgery.
No takes yet. Share an insight, caveat, or question.
Kim et al. (2023) conducted a meta-analysis in thoracic surgery (n=1,010). Regional nerve blocks vs. control was evaluated on incidence of postoperative delirium (POD) (OR 0.44, 95% CI 0.30 to 0.64, p=<0.001). Regional nerve blocks reduced the incidence of postoperative delirium (OR 0.44; 95% CI 0.30-0.64; p<0.001) and cognitive dysfunction (OR 0.43; 95% CI 0.24-0.76) after thoracic surgery.
Synapse has enriched 10 related papers. Consider them for comparative context: