Reports a rare case of acute necrotizing encephalopathy with unusual features in a European adult.
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Expands acute necrotizing encephalopathy spectrum to European adults with atypical features; hypothesis-generating, no practice change warranted.
Acute necrotizing encephalopathy (ANE) is a rare disease, characterized by the rapid development of multiple, symmetrical brain lesions, affecting the thalamus bilaterally, the brainstem tegmentum and the cerebellar medulla. The clinical picture consists of a rapidly deteriorating encephalopathy which develops 1 to 3 days after a prodromal febrile illness. ANE has been related to influenza A virus infection, but to date it has also been associated with other viruses and mycoplasma. We report a case of ANE, characterized by a combination of unusual features.
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Fasano et al. (2007) studied this question.
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