Key result
Patients with repaired Tetralogy of Fallot demonstrated decreased maximal exercise capacity (peak VO2 68.5% of predicted) but relatively preserved submaximal exercise capacity, which were negatively correlated with pulmonary regurgitation fraction and age at repair.
Population
158 patients with repaired tetralogy of Fallot, mean age at CPET 29.5 ± 12.2 years. Excluded: TOF with…
Design
Cross-sectional
Authors
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Reduced peak VO2 in repaired TOF supports serial CPET monitoring; leaves open whether targeting PR or LV function improves outcomes.
Cross-Sectional (n=158)
No
In patients with repaired tetralogy of Fallot, pulmonary regurgitation, LV function, and age at total repair are key determinants of late cardiopulmonary exercise performance.
Chen et al. (2015) conducted a cross-sectional in Repaired Tetralogy of Fallot (n=158). Repaired Tetralogy of Fallot vs. Predicted normal values was evaluated on Peak oxygen consumption (peak VO2) as a percentage of predicted value. Patients with repaired Tetralogy of Fallot demonstrated decreased maximal exercise capacity (peak VO2 68.5% of predicted) but relatively preserved submaximal exercise capacity, which were negatively correlated with pulmonary regurgitation fraction and age at repair.
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