Key result
In pregnant women with mild chronic hypertension, preenrollment blood pressure of 140-150/90-99 mm Hg increased the risk of adverse pregnancy outcomes compared to <140/90 mm Hg (OR 2.0; 95% CI 1.3-3.2).
Why the study?
Does lower preenrollment blood pressure (<140/90 mm Hg) reduce adverse pregnancy outcomes in women with mild chronic hypertension before 20 weeks of gestation?
Population
759 women with singleton pregnancy and chronic hypertension diagnosed before 20 weeks of gestation with…
Comparison
Preenrollment blood pressure 140-150/90-99 mm Hg… vs Preenrollment blood pressure <140/90 mm Hg
Design
Cohort
Authors
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Supports BP <140/90 mm Hg target in mild chronic hypertension; hypothesis-generating for randomized trials before 20 weeks.
Cohort (n=759)
Yes
Does lower preenrollment blood pressure (<140/90 mm Hg) reduce adverse pregnancy outcomes in women with mild chronic hypertension before 20 weeks of gestation?
Odds Ratio: 2 (95% CI 1.3–3.2)
Absolute Event Rate: 19% vs 10.7%
p-value: p=≤.001
In women with mild chronic hypertension before 20 weeks of gestation, maintaining blood pressure <140/90 mm Hg is associated with a significantly lower risk of adverse pregnancy outcomes.
Ankumah et al. (2014) conducted a cohort in mild chronic hypertension (n=759). Preenrollment blood pressure 140-150/90-99 mm Hg vs. Preenrollment blood pressure <140/90 mm Hg was evaluated on Composite of perinatal death, severe preeclampsia, placental abruption, and indicated preterm birth <35 weeks of gestation (OR 2.0, 95% CI 1.3-3.2, p=≤.001). In pregnant women with mild chronic hypertension, preenrollment blood pressure of 140-150/90-99 mm Hg increased the risk of adverse pregnancy outcomes compared to <140/90 mm Hg (OR 2.0; 95% CI 1.3-3.2).
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