Key result
Patch-free supra-annular AVR yields ~89% 5-year freedom from reinfection or reoperation in destructive PVE.
Why the study?
Prosthetic valve endocarditis complicated by complex paraannular aortic abscess remains a surgical challenge, prompting evaluation of a standardized, patch-free, supra-annular aortic valve replacement strategy avoiding complete root replacement.
Cohort (n=70)
No
A patch-free, supra-annular aortic valve replacement approach avoids complex root reconstruction and provides durable infection control and excellent mid-term survival in high-risk patients with complex prosthetic valve endocarditis.
May simplify management of complex prosthetic valve endocarditis; leaves open need for randomized trials versus root replacement.
Background: Prosthetic valve endocarditis (PVE) complicated by complex paraannular aortic abscess remains a surgical challenge. We aimed to evaluate the mid-term outcomes of a standardized, patch-free, supra-annular aortic valve replacement strategy that avoids complete root replacement in these high-risk patients. Methods: This retrospective, single-center study included 70 consecutive patients treated between 2015 and 2023 for complex aortic PVE using a consistent surgical protocol: radical debridement, supra-annular prosthetic valve implantation, inside the Valsalva sinuses, and external felt reinforcement-without annular or root patching. Follow-up included annual clinical and echocardiographic assessment (mean duration, 5.2 ± 1.3 years). The primary endpoint was freedom from the composite of reinfection or aortic reoperation. Secondary endpoints included survival, valve performance, and predictors of late adverse events. Results: < .01). Ninety-two percent of survivors were in New York Heart Association class I-II. Independent predictors of late events included EuroSCORE II >12% and incomplete abscess excision. Conclusions: Patch-free supra-annular valve replacement offers durable infection control and excellent hemodynamic outcomes, avoiding the need for complete root replacement in complex aortic PVE.
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Nasso et al. (2025) conducted a cohort in Prosthetic valve endocarditis complicated by para-annular aortic abscess (n=70). Modified patch-free supra-annular aortic valve replacement was evaluated on Freedom from the composite of definite PVE reinfection or aortic reoperation for any cause at 5 years (95% CI 82.1-96.2%). A standardized, patch-free supra-annular aortic valve replacement in patients with destructive prosthetic valve endocarditis achieved 89.2% freedom from reinfection or aortic reoperation at 5 years.
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