Why the study?
Does nateglinide affect the pharmacokinetics and anticoagulant properties of warfarin in healthy volunteers?
Population
12 healthy male subjects
Comparison
Nateglinide 120 mg 10 min before meals for 4… vs Single oral dose of warfarin 30 mg alone
Design
RCT, randomized two-group, two-way crossover, open-label
Follow-up
4 days per treatment period with a 7- to 14-day washout
Authors
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Supports concurrent nateglinide-warfarin use without dose adjustment; confirms absence of pharmacokinetic or pharmacodynamic interaction in an RCT.
Does nateglinide affect the pharmacokinetics and anticoagulant properties of warfarin in healthy volunteers?
Coadministration of nateglinide does not alter the pharmacokinetics or anticoagulant effects of warfarin in healthy volunteers.
Anderson et al. (2002) studied this question.
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