Why the study?
Does orlistat alter the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers?
Population
12 healthy volunteers
Comparison
Orlistat 120 mg oral three times a day for 16… vs Matching placebo three times a day for 16 days…
Design
RCT, randomized, two-way crossover, third-party blind, placebo-controlled
Follow-up
16 days per treatment period with a 3-week washout
Authors
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No dose adjustment or extra monitoring required for warfarin with orlistat; confirms absence of clinically relevant interaction in this RCT.
Does orlistat alter the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers?
Orlistat does not significantly alter the pharmacokinetics and pharmacodynamics of warfarin, suggesting no clinically significant drug-drug interaction.
Zhi et al. (1996) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: