Key result
Consumption of high-catechin green tea (400 mg/day) for 9 weeks did not significantly change serum adiponectin levels compared to low-catechin green tea (100 mg/day) in apparently healthy adults (net difference 0.35 mg/ml, p=0.61).
Why the study?
Does high catechin green tea consumption improve serum adiponectin levels and cardiovascular disease risk factors in apparently healthy subjects?
RCT (n=51)
Double-blind
Permuted block method
No
Does high catechin green tea consumption improve serum adiponectin levels and cardiovascular disease risk factors in apparently healthy subjects?
Mean Difference: 0.35 (95% CI -1.03–1.74)
Absolute Event Rate: 1.29% vs 1%
p-value: p=0.61
High-dose catechin green tea consumption for 9 weeks does not significantly alter serum adiponectin levels or cardiovascular risk factors compared to low-dose consumption in healthy subjects.
High-catechin green tea does not raise adiponectin; confirms null effect on this biomarker in healthy adults.
BACKGROUND: Previous observational studies have indicated that green tea (GT) consumption is associated with reduced mortality from cerebral infarction but not with mortality from cerebral hemorrhage. Therefore, we hypothesized that GT exerts a direct antiatherosclerotic effect without any effect on hypertension. To investigate this hypothesis, we focused on adiponectin that seems to be among the several key players in atherosclerosis. OBJECTIVE: The objective of this randomized controlled trial (RCT) was to assess whether the consumption of catechin-enriched GT affects serum adiponectin levels and cardiovascular disease (CVD) risk factors among apparently healthy subjects. DESIGN: A total of 51 individuals participated in the study. Eligible participants were randomly assigned into GT consumption groups with either high catechin (400 mg/day) or low catechin (100 mg/day). The study participants were asked to stop GT consumption for 2 weeks (washout period), following which they were to start drinking the provided GT beverages everyday for 9 weeks. The outcome measures were changes in the adiponectin levels and CVD risk factors (body weight, body mass index, waist circumference, blood pressure, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglyceride, fasting plasma glucose, as well as aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transpeptidase, uric acid, and high-sensitive C-reactive protein). RESULTS: After intervention for 9 weeks, we found no significant difference between the high- and low catechin group with respect to changes in the serum adiponectin level: 0.35 µg/ml (95% confidence interval (CI): -1.03, 1.74). Also, no significant difference was observed between the high- and low catechin groups with respect to changes in any of the measured CVD risk factors. CONCLUSION: This RCT showed no significant difference between the high- and low catechin groups with respect to changes in the serum adiponectin level and any CVD risk factors.
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Sone et al. (2011) conducted an RCT in Apparently healthy subjects (n=51). Catechin-enriched green tea vs. Low catechin green tea (100 mg/day) was evaluated on Change in serum adiponectin level (MD 0.35 mg/ml, 95% CI -1.03 to 1.74, p=0.61). Consumption of high-catechin green tea (400 mg/day) for 9 weeks did not significantly change serum adiponectin levels compared to low-catechin green tea (100 mg/day) in apparently healthy adults (net difference 0.35 mg/ml, p=0.61).
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