Thymoma should be considered as a possible etiology in patients presenting with pericardial masses and cardiac tamponade.
Thymoma warrants consideration in pericardial masses causing tamponade; this Level 5 case leaves open prospective diagnostic validation.
Thymoma is a rare tumour originating from the thymic epithelial cells. Here, we present a rare case of thymoma in a female patient in her early 60s, who presented for a clinical emergency. The tumour initially mimicked a primary pericardial tumour causing cardiac tamponade, but on surgical resection and subsequent histopathological examination, it was found to be a thymoma. This case emphasises the importance of considering thymoma as a possible aetiology in pericardial masses and highlights the diagnostic dilemmas associated with thymomas presenting in ectopic locations.
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Prakash et al. (2025) studied this question.
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