Population
Langendorff perfused isolated rabbit hearts
Comparison
30 minutes of left anterior descending coronary… vs Normal conditions (baseline)
Design
Preclinical
Follow-up
60 minutes (30 minutes occlusion, 30 minutes reperfusion)
Authors
Loading...
May explain ischemia-related arrhythmia vulnerability in heterogeneous myocardium; leaves open translation to human risk stratification or therapy.
Ischemia enhances dispersion of epicardial activation-recovery intervals at sites of histological inhomogeneity, providing a mechanistic explanation for increased arrhythmia susceptibility in infarcted or structurally abnormal hearts.
Gottwald et al. (1998) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: