Why the study?
Does dehydroascorbic acid inhibit the multiplication of HSV-1, influenza virus, and poliovirus in vitro?
Does dehydroascorbic acid inhibit the multiplication of HSV-1, influenza virus, and poliovirus in vitro?
Dehydroascorbic acid exhibits broad-spectrum antiviral activity in vitro against enveloped and non-enveloped DNA and RNA viruses, likely by interfering with viral assembly or envelopment.
Answers are grounded in this paper and cite their sources.
No clinical implications yet; hypothesis-generating for dehydroascorbic acid antiviral effects in vivo.
IN THE PRESENT STUDY, DEHYDROASCORBIC ACID INHIBITED THE MULTIPLICATION OF VIRUSES OF THREE DIFFERENT FAMILIES: herpes simplex virus type 1 (HSV-1), influenza virus type A and poliovirus type 1. Although dehydroascorbic acid showed some cytotoxicity at higher concentrations, the observed antiviral activity was not the secondary result of the cytotoxic effect of the reagent, as the inhibition of virus multiplication was observed at reagent concentrations significantly lower than those resulting in cytotoxicity. Characterization of the mode of the antiviral action of dehydroascorbic acid against HSV-1 revealed that the addition of reagent at any time post infection inhibited the formation of progeny infectious virus in the infected cells, and a one-step growth curve showed that the addition of reagent allowed formation for an additional 2 h, but then almost completely suppressed it. These results indicate that the reagent inhibits HSV-1 multiplication after the completion of viral DNA replication, probably at the step of the envelopment of viral nucleocapsids at the Golgi apparatus of infected cells.
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Uozaki et al. (2010) studied this question.
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