Population
Herpes simplex virus type 1 (HSV-1) in vitro model
Comparison
Adenosine deaminase inhibitor alone or in… vs Ara-hypoxanthine or coformycin
Design
Preclinical
Authors
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May support HSV-1 adjunctive strategies; leaves open human translation from animal data.
An adenosine deaminase inhibitor demonstrated direct antiviral activity against HSV-1 and strongly potentiated the inhibitory effect of adenine arabinoside.
Williams et al. (1975) studied this question.
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