What does this research mean for the field?

Titanium dioxide nanoparticles biogenically synthesized using Crotalaria pallida leaf extract demonstrate significant antibacterial, antioxidant, anti-angiogenic, and anticancer properties. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To synthesize titanium dioxide nanoparticles using Crotalaria pallida leaf extract and assess their antibacterial, antioxidant, antiangiogenic, and anticancer properties.

September 3, 2026Next MaterialsOpen Access

Biogenic synthesis of TiO₂ nanoparticles from Crotalaria pallida and their antibacterial, antioxidant, anti-angiogenic, and anticancer activities

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Authors

KIKirankumar Malleshappa IrannanavarKarnatak University AGAnjana Thatesh GaddigalKarnatak University PSParashuram ShivappaKarnatak University

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Implication

In vitro study demonstrates potent cytotoxic and antibacterial effects in cancer cell lines and bacteria, indicating broad therapeutic value for green-synthesized titanium dioxide nanoparticles.

Key Points

To synthesize titanium dioxide nanoparticles using Crotalaria pallida leaf extract and assess their antibacterial, antioxidant, antiangiogenic, and anticancer properties.
Synthesized TiO₂ nanoparticles using C. pallida leaf extract and characterized their structure, morphology, and stability via UV-vis, FTIR, XRD, DLS, SEM-EDS, and TEM.
Assessed biological activity through concentration-dependent antibacterial testing, DPPH radical scavenging assays, and chorioallantoic membrane (CAM) antiangiogenesis assays.
Evaluated in vitro anticancer efficacy and ROS-mediated apoptosis in human colorectal (HCT-116) and pancreatic (PANC-1) cancer cell lines over 72 hours.
Crystalline anatase-phase nanoparticles exhibited a 122 nm average hydrodynamic size, a +40.4 mV zeta potential, and concentration-dependent antibacterial activity favored against Gram-negative bacteria.
Free-radical scavenging assays showed enhanced antioxidant capacity for TiO₂ nanoparticles (IC₅₀ = 125.61 µg/mL) compared to crude plant extract (IC₅₀ = 181.96 µg/mL).
Cytotoxicity assays demonstrated dose- and time-dependent cell death with 72-hour IC₅₀ values of 71.55 µg/mL in HCT-116 cells and 19.72 µg/mL in PANC-1 cells accompanied by ROS-driven apoptosis.

Cite This Study

Irannanavar et al. (2026) studied this question.

synapsesocial.com/papers/6a9934cf636c6408cfa7c7ec https://doi.org/10.1016/j.nxmate.2026.103300

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Implication

In vitro study demonstrates potent cytotoxic and antibacterial effects in cancer cell lines and bacteria, indicating broad therapeutic value for green-synthesized titanium dioxide nanoparticles.

Biogenic synthesis of TiO₂ nanoparticles from Crotalaria pallida and their antibacterial, antioxidant, anti-angiogenic, and anticancer activities

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Cite This Study

Biogenic synthesis of TiO₂ nanoparticles from Crotalaria pallida and their antibacterial, antioxidant, anti-angiogenic, and anticancer activities

Discussion

Member takes

Implication

Key Points

Cite This Study

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