Key result
Adding peripheral electrical stimulation to bilateral arm training boosts ipsilesional prefrontal and motor activation.
Why the study?
Does peripheral electrical stimulation combined with bilateral arm training improve cortical hemodynamics and network organization compared to bilateral arm training alone in subacute stroke patients?
Does peripheral electrical stimulation combined with bilateral arm training improve cortical hemodynamics and network organization compared to bilateral arm training alone in subacute stroke patients?
Answers are grounded in this paper and cite their sources.
Combined peripheral electrical stimulation and bilateral arm training enhances cortical hemodynamic activation and network synchronization in subacute stroke patients compared to arm training alone.
SIGNIFICANCE: This study leverages functional near-infrared spectroscopy (fNIRS) to elucidate optically derived cortical network signatures underlying combined sensory-motor interventions in stroke rehabilitation. AIM: To characterize the synergistic effects of peripheral electrical stimulation (PES) and bilateral arm training (BAT) on cortical hemodynamics and functional network architecture using fNIRS. APPROACH: fNIRS signals were acquired from 24 subacute stroke patients. Wavelet amplitude and wavelet phase coherence were employed to quantify task-related hemodynamic activation and interregional synchronization within the 0.01-0.08 Hz frequency band. RESULTS: Compared with BAT alone, the PES-BAT paradigm elicited augmented hemodynamic activation in ipsilesional prefrontal and motor regions. The combined intervention further enhanced phase synchronization across distributed cortical networks and preserved interhemispheric coherence, counteracting maladaptive contralesional dominance. CONCLUSIONS: The fNIRS-based wavelet metrics effectively detect intervention-dependent modulation of cortical hemodynamics and network organization, highlighting the value of optical neuroimaging in assessing neuroplasticity during stroke rehabilitation.
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Li et al. (2026) studied Subacute stroke (n=24). Peripheral electrical stimulation (PES) and bilateral arm training (BAT) vs. Bilateral arm training (BAT) alone was evaluated on Task-related hemodynamic activation and interregional synchronization. The combined peripheral electrical stimulation and bilateral arm training paradigm elicited augmented hemodynamic activation in ipsilesional prefrontal and motor regions compared with training alone.
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