What does this research mean for the field?

Microneedle patches can effectively deliver liothyronine (LT3) transdermally, producing sustained elevated serum T3 levels in hypothyroid rats and demonstrating feasibility for improved hypothyroidism therapy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop and evaluate a polymer-based microneedle patch for the transdermal delivery of liothyronine to maintain stable thyroid hormone levels.

September 3, 2026Drug Delivery and Translational ResearchOpen Access

Delivery of liothyronine by microneedle patch for the treatment of hypothyroidism

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Authors

YGYasmine Gomaa THTasnuba Hasin MGMartin N. Griffin

Discussion

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Overview

Preclinical study demonstrates sustained liothyronine delivery via microneedle patches in hypothyroid rats, suggesting a viable alternative to oral thyroid hormone replacement.

Key Points

To develop and evaluate a polymer-based microneedle patch for the transdermal delivery of liothyronine to maintain stable thyroid hormone levels.
Fabricated microneedle patches incorporating varying doses of liothyronine within a poly(vinylpyrrolidone)-based formulation.
Evaluated skin puncture performance, in vitro delivery efficiency, and pharmacokinetic profiles in hypothyroid rats across three liothyronine doses (10 µg, 100 µg, and 1000 µg).
Microneedle patches effectively penetrated skin tissue and attained average liothyronine delivery efficiencies ranging between 41% and 71%.
Transdermal administration in hypothyroid rats elevated serum T3 concentrations for 18 to 24 hours in a dose-dependent, nonlinear manner.

Cite This Study

Gomaa et al. (2026) studied this question.

synapsesocial.com/papers/6a99353a636c6408cfa7d4fb https://doi.org/10.1007/s13346-026-02214-6

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September 3, 2026Drug Delivery and Translational ResearchOpen Access

Delivery of liothyronine by microneedle patch for the treatment of hypothyroidism

View Full Paper

Ask AI

Bookmark

Authors

YGYasmine Gomaa THTasnuba Hasin MGMartin N. Griffin

Discussion

Member takes

Overview

Preclinical study demonstrates sustained liothyronine delivery via microneedle patches in hypothyroid rats, suggesting a viable alternative to oral thyroid hormone replacement.

Key Points

To develop and evaluate a polymer-based microneedle patch for the transdermal delivery of liothyronine to maintain stable thyroid hormone levels.
Fabricated microneedle patches incorporating varying doses of liothyronine within a poly(vinylpyrrolidone)-based formulation.
Evaluated skin puncture performance, in vitro delivery efficiency, and pharmacokinetic profiles in hypothyroid rats across three liothyronine doses (10 µg, 100 µg, and 1000 µg).
Microneedle patches effectively penetrated skin tissue and attained average liothyronine delivery efficiencies ranging between 41% and 71%.
Transdermal administration in hypothyroid rats elevated serum T3 concentrations for 18 to 24 hours in a dose-dependent, nonlinear manner.

Cite This Study

Gomaa et al. (2026) studied this question.

synapsesocial.com/papers/6a99353a636c6408cfa7d4fb https://doi.org/10.1007/s13346-026-02214-6

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