What does this research mean for the field?

Exposure to environmental pollutants significantly increases the risk of adverse mental, neurodevelopmental, and reproductive health outcomes across the lifespan through shared biological pathways such as oxidative stress and neuroinflammation. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To consolidate current evidence regarding the impacts of diverse environmental pollutants on mental, neurodevelopmental, reproductive, and pregnancy outcomes and identify their shared biological mechanisms.

September 3, 2026Journal of Psychosexual HealthOpen Access

Climate Change as a Determinant of Mental and Physical Health: A Review

View Full Paper

Ask AI

Bookmark

Authors

ASAbhinav Sahay UMUpanshu Mishra ASArundhati Sharma

Discussion

Member takes

Overview

Narrative review reveals widespread mental and reproductive harm from diverse environmental pollutants in vulnerable populations, highlighting shared pathways like oxidative stress and inflammation.

Key Points

To consolidate current evidence regarding the impacts of diverse environmental pollutants on mental, neurodevelopmental, reproductive, and pregnancy outcomes and identify their shared biological mechanisms.
Conducted a narrative review of peer-reviewed literature published from 2000 to 2025 using PubMed/MEDLINE, Scopus, and Web of Science.
Synthesized findings from systematic reviews, meta-analyses, cohort studies, biomonitoring investigations, and mechanistic research using the exposome framework.
Consistent associations were identified between exposures to particulate matter, nitrogen dioxide, PFAS, heavy metals, bisphenols, and microplastics and heightened risks of depression, anxiety, neurodevelopmental deficits, and poor pregnancy or fetal outcomes.
Shared pathogenic mechanisms driving these multisystem adverse effects include oxidative stress, neuroinflammation, endocrine disruption, mitochondrial dysfunction, immune dysregulation, and epigenetic alterations.
Combined exposures to multiple pollutants demonstrated additive or synergistic toxicity, with pregnant women, developing children, and socio-economically disadvantaged populations exhibiting the greatest vulnerability.

Cite This Study

Sahay et al. (2026) studied this question.

synapsesocial.com/papers/6a993547636c6408cfa7d65b https://doi.org/10.1177/26318318261479108

View Full Paper

Ask AI

Bookmark

September 3, 2026Journal of Psychosexual HealthOpen Access

Climate Change as a Determinant of Mental and Physical Health: A Review

View Full Paper

Ask AI

Bookmark

Authors

ASAbhinav Sahay UMUpanshu Mishra ASArundhati Sharma

Discussion

Member takes

Overview

Narrative review reveals widespread mental and reproductive harm from diverse environmental pollutants in vulnerable populations, highlighting shared pathways like oxidative stress and inflammation.

Key Points

To consolidate current evidence regarding the impacts of diverse environmental pollutants on mental, neurodevelopmental, reproductive, and pregnancy outcomes and identify their shared biological mechanisms.
Conducted a narrative review of peer-reviewed literature published from 2000 to 2025 using PubMed/MEDLINE, Scopus, and Web of Science.
Synthesized findings from systematic reviews, meta-analyses, cohort studies, biomonitoring investigations, and mechanistic research using the exposome framework.
Consistent associations were identified between exposures to particulate matter, nitrogen dioxide, PFAS, heavy metals, bisphenols, and microplastics and heightened risks of depression, anxiety, neurodevelopmental deficits, and poor pregnancy or fetal outcomes.
Shared pathogenic mechanisms driving these multisystem adverse effects include oxidative stress, neuroinflammation, endocrine disruption, mitochondrial dysfunction, immune dysregulation, and epigenetic alterations.
Combined exposures to multiple pollutants demonstrated additive or synergistic toxicity, with pregnant women, developing children, and socio-economically disadvantaged populations exhibiting the greatest vulnerability.

Cite This Study

Sahay et al. (2026) studied this question.

synapsesocial.com/papers/6a993547636c6408cfa7d65b https://doi.org/10.1177/26318318261479108

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark