What question did this study set out to answer?

To review the current evidence on how chemical and physical environmental pollutants impair embryo-fetal development and identify the biological mechanisms underlying adverse reproductive outcomes.

October 1, 2025Journal of Assisted Reproduction and GeneticsOpen Access

The silent crisis: investigating the impact of environmental pollutants on embryo-fetal development: a narrative review of the Group of Special Interest for Environment of the Italian Society of Fertility and Sterility and Reproductive Medicine

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Authors

AAAlessandra AlteriVita-Salute San Raffaele University ANAndrea Di NisioPegaso University VPValerio PisaturoVita-Salute San Raffaele University

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Implication

Narrative review reveals environmental contaminants disrupt early embryo-fetal development in humans, highlighting the urgent need for mechanistic research and regulatory policies.

Key Points

To review the current evidence on how chemical and physical environmental pollutants impair embryo-fetal development and identify the biological mechanisms underlying adverse reproductive outcomes.
Conducted a comprehensive literature search of NCBI PubMed up to August 15, 2025, performed by two independent reviewers.
Evaluated preclinical and clinical evidence on exposure to endocrine-disrupting chemicals, particulate matter, heavy metals, and heat stress across reproductive stages.
Chemical and physical pollutants impair critical reproductive events, including gametogenesis, fertilization, blastocyst implantation, and embryogenesis.
Mechanistic pathways linking specific environmental exposures to reproductive failure remain insufficiently characterized, hindering targeted clinical interventions and regulatory policymaking.

Cite This Study

Alteri et al. (2025) studied this question.

synapsesocial.com/papers/6a9ca0a08662eb246c41747b https://doi.org/10.1007/s10815-025-03653-9

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Implication

Narrative review reveals environmental contaminants disrupt early embryo-fetal development in humans, highlighting the urgent need for mechanistic research and regulatory policies.

The silent crisis: investigating the impact of environmental pollutants on embryo-fetal development: a narrative review of the Group of Special Interest for Environment of the Italian Society of Fertility and Sterility and Reproductive Medicine

Discussion

Member takes

Implication

Key Points

Cite This Study

The silent crisis: investigating the impact of environmental pollutants on embryo-fetal development: a narrative review of the Group of Special Interest for Environment of the Italian Society of Fertility and Sterility and Reproductive Medicine

Discussion

Member takes

Implication

Key Points

Cite This Study

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