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November 18, 2025Reproductive MedicineOpen Access

Environmental Pollution, Endocrine Disruptors, and Metabolic Status: Impact on Female Fertility—A Narrative Review

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Authors

CPCristina Diana POPESCURSRomina-Marina SimaMPMircea-Octavian Poenaru

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Overview

Narrative review shows endocrine disruptors diminish ovarian reserve in females, highlighting obesity's role in fertility.

Key Points

  • This review synthesizes evidence on how environmental pollutants and metabolic factors affect female fertility.
  • Conducted narrative review of studies from 2019 to 2025
  • Utilized databases including PubMed and Google Scholar
  • Prioritized human evidence and accounted for confounding factors
  • Environmental pollutants linked to reduced ovarian reserve and oocyte quality
  • PFAS exposure associated with lower fecundability
  • PM2.5 and NO2 correlated with decreased AMH and AFC levels

Cite This Study

POPESCU et al. (2025) studied this question.

synapsesocial.com/papers/6924fee6c0ce034ddc351748https://doi.org/10.3390/reprodmed6040037
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mitigation of Environmental Exposure, Pollutants, and Endocrine Disruptors to Reproductive Health: A Literature Review2025 · 2 citations
  2. 2Assessment of ovarian dysfunction induced by environmental toxins: a systematic review2025 · 8 citations
  3. 3The silent crisis: investigating the impact of environmental pollutants on embryo-fetal development: a narrative review of the Group of Special Interest for Environment of the Italian Society of Fertility and Sterility and Reproductive Medicine2025 · 9 citations
  4. 4Association of Environmental Pollution and Infertility – A Mini-Review2025 · 1 citations
  5. 5Environmental Chemicals and Female Reproductive Health: Unraveling Mechanisms and Societal Impacts — A Narrative Review2025 · 5 citations