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September 3, 2026Radiology

Exploring the Diagnostic Utility of Ferumoxytol for Brachial Plexus MR Neurography

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Authors

FEFalko EnsleUniversity of ZurichETEk T. TanHospital for Special SurgerySQSophie C. QuelerManhattan Eye, Ear and Throat Hospital

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Implication

Comparative imaging study demonstrates improved vascular suppression with ferumoxytol in brachial plexus neurography, suggesting enhanced nerve visualization over standard noncontrast scans.

Key Points

  • To assess the diagnostic efficacy and vascular suppression capability of ferumoxytol compared with noncontrast and gadolinium-enhanced protocols in brachial plexus MR neurography.
  • Evaluated 3D short-tau inversion-recovery fast spin-echo (STIR-FSE) sequences in brachial plexus MR neurography using ferumoxytol.
  • Compared ferumoxytol image quality, vascular suppression, and nerve conspicuity directly against noncontrast and gadolinium-enhanced acquisitions.
  • Ferumoxytol significantly improved vascular suppression compared with both noncontrast and gadolinium-enhanced 3D STIR-FSE sequences.
  • Conspicuity of multiple brachial plexus nerve branches was substantially enhanced with ferumoxytol compared to noncontrast scans.
  • Diagnostic detection of abnormal nerve findings remained equivalent across imaging protocols (p ≥ .48).

Cite This Study

Ensle et al. (2026) studied this question.

synapsesocial.com/papers/6a9935d8636c6408cfa7e574https://doi.org/10.1148/radiol.254051
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relaxivity of Ferumoxytol at 1.5 T and 3.0 T2017 · 95 citations
  2. 2Three-dimensional MR Neurography of the Brachial Plexus: Vascular Suppression with Low-dose Ferumoxytol2022 · 23 citations
  3. 3Biodistribution of gadolinium‐based contrast agents, including gadolinium deposition2009 · 535 citations
  4. 4Contrast-enhanced MR Angiography without Gadolinium-based Contrast Material: Clinical Applications Using Ferumoxytol2022 · 23 citations
  5. 5Thoracic Outlet: Assessment with MR Imaging in Asymptomatic and Symptomatic Populations2003 · 191 citations