What does this research mean for the field?

Immunometabolic adaptation, driven by the granuloma microenvironment, is a key determinant of neutrophil plasticity in tuberculosis, regulating the switch between protective antimicrobial activity and pathological inflammation. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Examine how metabolic remodeling within the tuberculosis granuloma microenvironment governs neutrophil phenotypic plasticity between antimicrobial defense and pathological tissue damage.

September 3, 2026Cell Biology InternationalOpen Access

Immunometabolic Control of Neutrophil Plasticity in Tuberculosis

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Examine how metabolic remodeling within the tuberculosis granuloma microenvironment governs neutrophil phenotypic plasticity between antimicrobial defense and pathological tissue damage.
Synthesized evidence on granuloma microenvironmental pressures, including hypoxia, nutrient limitation, iron dysregulation, and extracellular acidosis.
Evaluated regulatory metabolic signaling networks, focusing on HIF-1α, mTOR/AMPK signaling, glycolysis, the pentose phosphate pathway, and redox control systems.
Environmental pressures within tuberculous granulomas remodel neutrophil metabolism, shifting phenotypes from protective antimicrobial containment toward destructive inflammation characterized by excessive NETosis, matrix destruction, and ferroptotic stress.
HIF-1α and mTOR/AMPK regulatory axes function as key metabolic checkpoints directing neutrophil functional adaptation and survival under severe nutrient and oxygen deprivation.

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Implication

Review delineates immunometabolic regulation of neutrophil plasticity within granulomas during tuberculosis, highlighting metabolic checkpoints as targets for host-directed therapies.

Cite This Study

Hamdan et al. (2026) studied this question.

synapsesocial.com/papers/6a9935d8636c6408cfa7e70d https://doi.org/10.1002/cbin.70205

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Implication

Review delineates immunometabolic regulation of neutrophil plasticity within granulomas during tuberculosis, highlighting metabolic checkpoints as targets for host-directed therapies.

Immunometabolic Control of Neutrophil Plasticity in Tuberculosis

Key Points

Discussion

Implication

Cite This Study

Immunometabolic Control of Neutrophil Plasticity in Tuberculosis

Key Points

Discussion

Implication

Cite This Study

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