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July 8, 2026International Journal of Molecular SciencesOpen Access

Tuberculosis and Cellular Metabolism: Insights into the Crosstalk Between Macrophage Immunometabolism and Muscle Dysregulation

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Authors

MHMohammed HaiderHAHalemah AlSaeedFAFatema Al‐Rashed

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Overview

Review reveals how Mycobacterium tuberculosis alters macrophage metabolism, linking it to muscle dysfunction and cachexia.

Key Points

  • This review aims to explore the interaction between Mycobacterium tuberculosis and host metabolic responses, particularly in macrophages and skeletal muscle.
  • Synthesis of current understanding regarding Mtb's impact on macrophage immunometabolism and systemic effects.
  • Analysis of molecular mechanisms including glycolytic shifts and cytokine-mediated interactions.
  • Exploration of proposed biomarkers and therapeutic strategies targeting macrophage metabolism.
  • Mycobacterium tuberculosis induces a Warburg-like metabolic switch in macrophages, linked to muscle proteolysis.
  • Cytokines such as TNF-α and IL-6 mediate processes connecting infected macrophages to muscle dysregulation.
  • Proposed immunometabolic biomarkers could aid in TB diagnosis and treatment monitoring, pending clinical validation.

Cite This Study

Haider et al. (2026) studied this question.

synapsesocial.com/papers/6a4de976d2ea289ef6283923https://doi.org/10.3390/ijms27136062
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetically diverse Mycobacterium tuberculosis isolates manipulate inflammasome activation and IL-1β secretion independently of macrophage metabolic rewiring2024
  2. 2Systems analysis reveals alternate metabolic states adopted by <i>Mycobacterium tuberculosis</i> across species2026 · 1 citations
  3. 3Immunometabolic Control of Neutrophil Plasticity in Tuberculosis2026
  4. 4Editorial: Investigating lung biology, metabolism, and host susceptibility in mycobacterial infections2026
  5. 5PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment2025