What does this research mean for the field?

Underlying diseases, moderate to severe preoperative pulmonary artery hypertension, and longer aortic cross-clamping time are independent risk factors for healthcare-associated infections in children following cardiac surgery, with Gram-negative bacilli being the predominant pathogens. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify clinical risk factors and characterize microbiological profiles associated with healthcare-associated infections following pediatric open-heart surgery.

September 3, 2026Infection and Drug ResistanceOpen Access

Risk Factors and Microbiological Characterization of Healthcare Associated Infection Post Cardiac Surgery Among Children in Beijing, China

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Authors

YXYan XuBeijing Children’s Hospital LSLei ShenJiangsu University NDNan DingBeijing Children’s Hospital

Discussion

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Implication

Retrospective study uncovers high infection rates and specific risk factors in pediatric open-heart surgery patients, indicating key targets for infection control and antimicrobial stewardship.

Key Points

To identify clinical risk factors and characterize microbiological profiles associated with healthcare-associated infections following pediatric open-heart surgery.
Conducted a single-center retrospective study of N=1206 pediatric patients with congenital heart disease who underwent open-heart surgery between July 1, 2022, and June 30, 2025, at Beijing Children’s Hospital.
Used multivariate logistic regression to evaluate clinical variables, including pulmonary hypertension, surgical duration, and glucocorticoid use, for independent associations with postoperative infections.
The overall healthcare-associated infection rate was 13.6% among 1206 pediatric patients.
Postoperative infection was independently associated with underlying diseases (OR = 12.342; 95% CI: 5.744–26.518; P < 0.001), moderate preoperative pulmonary artery hypertension (OR = 3.141; 95% CI: 1.311–7.527; P = 0.010), severe preoperative pulmonary artery hypertension (OR = 3.312; 95% CI: 1.407–7.797; P = 0.006), and longer aortic cross-clamping time (OR = 1.026; 95% CI: 1.008–1.045; P = 0.004).
Bacteria accounted for 55.9% (133/238) of detected organisms, with Gram-negative bacilli comprising 89.5% (119/133) of bacterial isolates, among which Klebsiella pneumoniae was the sole multidrug-resistant organism.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/6a9935e5636c6408cfa7e8bf https://doi.org/10.2147/idr.s623693

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Implication

Retrospective study uncovers high infection rates and specific risk factors in pediatric open-heart surgery patients, indicating key targets for infection control and antimicrobial stewardship.

Risk Factors and Microbiological Characterization of Healthcare Associated Infection Post Cardiac Surgery Among Children in Beijing, China

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk Factors and Microbiological Characterization of Healthcare Associated Infection Post Cardiac Surgery Among Children in Beijing, China

Discussion

Member takes

Implication

Key Points

Cite This Study

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