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September 3, 2026American Heart Journal Plus Cardiology Research and PracticeOpen Access

Arrhythmic risk in ventricular cardiac tumors: A comparative imaging and clinical analysis

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Why the study?

Ventricular arrhythmias and sudden cardiac death are serious complications of cardiac tumors, but predictors of arrhythmic risk in patients with ventricular masses remain poorly defined.

Population

34 patients with ventricular cardiac masses

Comparison

Patients with VA/SCD presentation vs patients without significant ventricular arrhythmia

Design

Retrospective comparative cohort study

Follow-up

Median 3 years

Key result

Larger tumor size (6.8 vs 2.3 cm, p<0.001) and solitary morphology (100% vs 60.9%, p=0.017) were associated with ventricular arrhythmia or sudden cardiac death in patients with ventricular masses.

Authors

MRMohamed S. RiadMAMohamed M. AbdelfadilMHMostafa Wanees Ahmed El Husseny

Discussion

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Overview

May inform arrhythmia surveillance decisions for ventricular masses; observational data leaves open prospective validation before practice change.

Key Points

  • To identify clinical, anatomical, and imaging features associated with ventricular arrhythmias and sudden cardiac death in patients with ventricular cardiac masses.
  • Retrospective comparative cohort study of N=34 patients with ventricular cardiac masses from a single registry (2012–2024) with a median follow-up of 3 years.
  • Compared patients presenting with sustained ventricular tachyarrhythmias, sudden cardiac arrest, or arrhythmic death (n=11) to non-arrhythmic controls (n=23) using Mann–Whitney U and Fisher's exact tests.
  • Arrhythmic presentations occurred in 32.4% (11/34) of patients, who were older (median 14 vs. 1 year, p=0.044) and had higher rates of syncope (45.5% vs. 0%, p=0.002) and palpitations (63.6% vs. 21.7%, p=0.026).
  • Arrhythmic cases had significantly larger tumors (median 6.8 vs. 2.3 cm, p<0.001) and exclusively solitary masses (100% vs. 60.9%, p=0.017), with late gadolinium enhancement present in 90.9% vs. 57.9% (p=0.100).
  • Fibromas and vascular tumors predominated in arrhythmic presentations, whereas rhabdomyomas occurred only in non-arrhythmic patients (p=0.002); ventricular function and hemodynamics were similar across groups.

Study Design

Type

Cohort (n=34)

Multicenter

No

Structured PICO

P
Population
34 patients with ventricular cardiac masses followed for a median of 3 years to identify predictors of ventricular arrhythmia or sudden cardiac death.
O
Outcome
Ventricular arrhythmia/SCD (VA/SCD) presentation (sustained ventricular tachyarrhythmia, survived sudden cardiac arrest, or arrhythmic death)hard clinical

In patients with ventricular cardiac masses, arrhythmic risk is associated with larger, solitary tumors and specific histologies rather than impaired ventricular function.

Limitations

  • Confounded by tumor type, especially pediatric multifocal rhabdomyomas.
  • Patterns were confounded by tumor type, especially pediatric multifocal rhabdomyomas

Cite This Study

Riad et al. (2026) conducted a cohort in Ventricular cardiac masses (n=34). Clinical, anatomical, and imaging features (e.g., tumor size, morphology) was evaluated on Ventricular arrhythmia or sudden cardiac death (VA/SCD). Larger tumor size (6.8 vs 2.3 cm, p<0.001) and solitary morphology (100% vs 60.9%, p=0.017) were associated with ventricular arrhythmia or sudden cardiac death in patients with ventricular masses.

synapsesocial.com/papers/6a9935f3636c6408cfa7eacchttps://doi.org/10.1016/j.ahjo.2026.100879
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