Key result
Ventricular arrhythmias were observed in 22% of patients with sickle cell anemia and were independently associated with male sex, impaired global longitudinal strain, and decreased platelet count.
Why the study?
Sudden death is a leading cause of death in adults with sickle cell anemia, but the prevalence and determinants of ventricular arrhythmias in this population are poorly studied.
Population
100 patients with sickle cell anemia referred to evaluate cardiac function
Comparison
Patients with vs without ventricular arrhythmias
Design
Prospective registry study
Authors
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GLS may aid ventricular arrhythmia risk stratification in sickle cell anemia; observational data leave open prospective validation before clinical adoption.
Cross-Sectional (n=100)
In patients with sickle cell anemia, ventricular arrhythmias are common and can be predicted by impaired global longitudinal strain, suggesting its value for rhythmic risk stratification.
d’Humières et al. (2023) conducted a cross-sectional in Sickle cell anemia (n=100). Clinical and echocardiographic risk factors (male sex, impaired GLS, decreased platelet count) was evaluated on Occurrence of ventricular arrhythmia (VA), defined as sustained or nonsustained ventricular tachycardia (VT), >500 premature ventricular contractions (PVCs) on 24h-Holter, or a recent history of VT ablation. Ventricular arrhythmias were observed in 22% of patients with sickle cell anemia and were independently associated with male sex, impaired global longitudinal strain, and decreased platelet count.
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