Why the study?
VPC is associated with an increased risk of HF, but the role of VPC burden in long-term prognosis required clarification.
Does a moderate or high burden of ventricular premature complexes increase the risk of cardiovascular mortality in patients undergoing 24-hour Holter monitoring?
Population
19,527 patients undergoing 24-h Holter ECG monitoring for palpitation, syncope, or suspected arrhythmias
Comparison
Moderate (1,000-10,000/day) and high (>10,000/day) vs low (<1,000/day) VPC burden
Design
Single-center retrospective population-based cohort study
Authors
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Supports VPC burden stratification on Holter for CV mortality risk; extends observational data but leaves causality and intervention effects open.
Does a moderate or high burden of ventricular premature complexes increase the risk of cardiovascular mortality in patients undergoing 24-hour Holter monitoring?
A moderate (1,000-10,000/day) or high (>10,000/day) burden of ventricular premature complexes is independently associated with an increased risk of cardiovascular mortality.
Lee et al. (2022) studied this question.