Key result
High ventricular premature complex variability (alpha VPC > 3.0) was associated with a significantly lower 4-year survival rate compared to alpha VPC ≤ 0.3 (59% vs 97%).
Why the study?
Does increased VPC variability (alpha VPC > 3.0) predict mortality in patients with coronary artery disease and frequent VPCs?
Population
100 patients with coronary artery disease and ≥ 10 VPCs/hour
Comparison
High ventricular premature complex variability vs Low ventricular premature complex variability
Design
Cohort
Follow-up
mean 3.1 years
Authors
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High alpha VPC may flag higher mortality risk in CAD patients with frequent VPCs; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=100)
Does increased VPC variability (alpha VPC > 3.0) predict mortality in patients with coronary artery disease and frequent VPCs?
Absolute Event Rate: 59% vs 97%
Increased VPC variability quantified by nonlinear dynamics (alpha VPC > 3.0) is an independent predictor of total mortality and sudden cardiac death in patients with coronary artery disease.
Malík et al. (1996) conducted a cohort in Coronary artery disease with ≥10 VPCs/hour (n=100). High VPC variability (alpha VPC > 3.0) vs. Low VPC variability (alpha VPC ≤ 0.3) was evaluated on Total mortality (reported as 4-year survival rate). High ventricular premature complex variability (alpha VPC > 3.0) was associated with a significantly lower 4-year survival rate compared to alpha VPC ≤ 0.3 (59% vs 97%).
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