Key result
Left ventricular global longitudinal strain offered independent prognostic value for cardiovascular events in patients with aortic stenosis (HR 1.18; 95% CI 1.07-1.30; P=0.001).
Why the study?
CMR detects replacement myocardial fibrosis non-invasively but is limited for widespread use, prompting evaluation of LV-GLS as a surrogate marker and prognostic tool.
Does LV-GLS predict adverse cardiovascular outcomes in patients with moderate-severe aortic stenosis and preserved LVEF?
Population
151 hypertensive patients (derivation cohort) and 261 moderate-severe aortic stenosis patients with LVEF ≥50% (outcome cohort)
Comparison
LV-GLS >−15.0% vs LV-GLS between −21.0% and −15.0% vs LV-GLS <−21.0%
Design
Derivation and validation cohort study
Follow-up
16 [3.1, 42.0] months
Authors
Loading...
May support risk stratification in moderate-severe aortic stenosis with preserved LVEF; hypothesis-generating, needs prospective validation.
Cohort (n=412)
Does LV-GLS predict adverse cardiovascular outcomes in patients with moderate-severe aortic stenosis and preserved LVEF?
Hazard Ratio: 1.18 (95% CI 1.07–1.3)
p-value: p=0.001
LV-GLS thresholds associated with replacement myocardial fibrosis provide independent prognostic value for risk-stratifying patients with moderate-severe aortic stenosis and preserved LVEF.
Chin et al. (2021) conducted a cohort in Aortic stenosis (n=412). Left ventricular global longitudinal strain (LV-GLS) vs. LV-GLS <-21.0% was evaluated on Composite of cardiovascular mortality, heart failure hospitalization, myocardial infarction and cerebrovascular events (HR 1.18, 95% CI 1.07-1.30, p=0.001). Left ventricular global longitudinal strain offered independent prognostic value for cardiovascular events in patients with aortic stenosis (HR 1.18; 95% CI 1.07-1.30; P=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: