Key result
Left ventricular global longitudinal strain independently predicted all-cause mortality in patients with aortic stenosis and preserved ejection fraction (HR 1.05; 95% CI 1.03-1.07; P<0.001).
Why the study?
Does left ventricular global longitudinal strain (LV-GLS) predict mortality in patients with moderate to severe aortic stenosis and preserved ejection fraction?
Population
395 patients with moderate to severe and paradoxical severe aortic stenosis and preserved ejection fraction…
Comparison
Left ventricular global longitudinal strain… vs Standard clinical and echocardiographic parameters
Design
Cohort
Follow-up
4.4±1.4 years
Authors
Loading...
May refine risk stratification in aortic stenosis; hypothesis-generating and requires prospective validation before practice change.
Cohort (n=395)
Does left ventricular global longitudinal strain (LV-GLS) predict mortality in patients with moderate to severe aortic stenosis and preserved ejection fraction?
Hazard Ratio: 1.05 (95% CI 1.03–1.07)
p-value: p=<0.001
LV-GLS provides incremental prognostic value beyond standard clinical and echocardiographic parameters in patients with moderate to severe aortic stenosis and preserved ejection fraction.
Kusunose et al. (2014) conducted a cohort in Aortic stenosis with preserved ejection fraction (n=395). Left ventricular global longitudinal strain (LV-GLS) vs. Standard clinical and echocardiographic parameters was evaluated on All-cause mortality (HR 1.05, 95% CI 1.03-1.07, p=<0.001). Left ventricular global longitudinal strain independently predicted all-cause mortality in patients with aortic stenosis and preserved ejection fraction (HR 1.05; 95% CI 1.03-1.07; P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: