Why the study?
While left ventricular global longitudinal strain is associated with long-term outcomes in severe aortic stenosis, its prognostic value in moderate aortic stenosis remains unknown.
Does impaired left ventricular global longitudinal strain predict higher all-cause mortality in patients with moderate aortic stenosis and preserved ejection fraction?
Does impaired left ventricular global longitudinal strain predict higher all-cause mortality in patients with moderate aortic stenosis and preserved ejection fraction?
Impaired global longitudinal strain (>-15.2%) is associated with significantly higher long-term mortality in patients with moderate aortic stenosis and preserved ejection fraction.
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Impaired GLS was associated with higher mortality in moderate AS; hypothesis-generating for risk stratification, should not yet change practice.
BACKGROUND: Left ventricular global longitudinal strain (GLS) is associated with long-term outcomes of patients with severe aortic stenosis. However, its prognostic value in patients with moderate aortic stenosis remains unknown. METHODS: ) and left ventricular ejection fraction ≥50% were identified. GLS was assessed by 2-dimensional strain imaging using speckle-tracking method. All-cause mortality was assessed according to the median GLS value. Mortality rates at 1, 3, 5 years were 2%, 10%, 20%, respectively, in patients with GLS >-15.2% and 2%, 5%, 6% in those with GLS ≤-15.2%. CONCLUSIONS: Impaired GLS in moderate aortic stenosis patients is associated with higher mortality rates even among those undergoing aortic valve replacement.
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Zhu et al. (2020) studied this question.
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