Key result
Resting GLS <|9|% linked to ~118% higher all-cause mortality, with stress GLS adding prognostic value.
Why the study?
Does global longitudinal strain measured at rest and during dobutamine stress echocardiography predict mortality in patients with low ejection fraction, low-gradient aortic stenosis?
Population
126 patients with low LV ejection fraction and low-gradient aortic stenosis prospectively enrolled in a…
Comparison
Global longitudinal strain measurement at rest… vs Patients with rest GLS >|9|% or stress GLS >|10|%
Design
Cohort
Follow-up
3 years
Authors
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GLS may aid risk stratification in low-EF low-gradient AS; hypothesis-generating and requires prospective validation before guiding decisions.
Cohort (n=126)
Yes
Does global longitudinal strain measured at rest and during dobutamine stress echocardiography predict mortality in patients with low ejection fraction, low-gradient aortic stenosis?
Effect estimate: HR 2.18
Absolute Event Rate: 49% vs 68%
p-value: p=0.015
Global longitudinal strain measured at rest and during dobutamine stress echocardiography provides independent prognostic value for mortality in patients with low-ejection fraction, low-gradient aortic stenosis.
Dahou et al. (2015) conducted a cohort in Low LV ejection fraction, low-gradient aortic stenosis (n=126). Resting global longitudinal strain (GLS) <|9|% vs. Resting GLS >|9|% was evaluated on All-cause mortality (reported as 3-year survival rate) (HR 2.18, p=0.015). Resting global longitudinal strain <|9|% was independently associated with increased all-cause mortality (HR 2.18; P=0.015), with stress GLS providing incremental prognostic value.
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