What is the clinical evidence from this study?

Study design: Cohort. Population: Severe asymptomatic aortic stenosis with normal ejection fraction (n=79). Intervention: Left ventricular global longitudinal strain (GLS). Primary outcome: Cardiac death and aortic valve replacement driven by symptom development (HR 1.14, 95% CI 1.01-1.28, p=0.037).

What question did this study set out to answer?

To determine if global longitudinal strain (GLS) can guide risk assessment in asymptomatic aortic stenosis patients.

September 25, 2012Circulation Cardiovascular ImagingOpen Access

Association of Myocardial Deformation With Outcome in Asymptomatic Aortic Stenosis With Normal Ejection Fraction

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Key result

Left ventricular global longitudinal strain predicted cardiac death and symptom-driven aortic valve replacement in severe asymptomatic aortic stenosis (HR 1.14; 95% CI 1.01-1.28; P=0.037).

Why the study?

Does left ventricular global longitudinal strain predict cardiac death and symptom-driven aortic valve replacement in patients with severe asymptomatic aortic stenosis?

Population

79 patients with severe asymptomatic aortic stenosis

Design

Cohort

Follow-up

23 ± 20 months

Authors

TYTeerapat YingchoncharoenRamathibodi Hospital CGConrad GibbyRocky Mountain University of Health Professions LRL. Leonardo RodriguezCardiac Imaging

Discussion

Member takes

Overview

May support GLS for risk stratification in asymptomatic severe AS; hypothesis-generating pending prospective validation.

Key Points

To determine if global longitudinal strain (GLS) can guide risk assessment in asymptomatic aortic stenosis patients.
Prospectively followed 79 patients with asymptomatic severe aortic stenosis.
Measured global longitudinal strain and conducted standard echocardiography.
Utilized multivariable Cox regression to analyze associations with cardiac death and AV replacement.
3 patients experienced cardiac death, and 49 underwent AV replacement over a mean follow-up of 23 months.
GLS predicted outcomes with a hazard ratio of 1.14 (95% CI, 1.01-1.28; P=0.037).
A mean absolute GLS <15% indicated significantly higher mortality, enhancing prognostic value beyond other risk metrics.

Study Design

Type

Cohort (n=79)

Structured PICO

Does left ventricular global longitudinal strain predict cardiac death and symptom-driven aortic valve replacement in patients with severe asymptomatic aortic stenosis?

Population

79 patients with severe asymptomatic aortic stenosis and normal ejection fraction, followed for a mean of 23 months.

Exposure

Left ventricular global longitudinal strain (GLS) assessment via speckle strain echocardiography

Outcome

Composite of cardiac death and aortic valve replacement driven by symptom developmentcomposite

Main Result

Hazard Ratio: 1.14 (95% CI 1.01–1.28)

p-value: p=0.037

Global longitudinal strain provides incremental prognostic value for predicting cardiac death and symptom-driven aortic valve replacement in patients with severe asymptomatic aortic stenosis.

Cite This Study

Yingchoncharoen et al. (2012) conducted a cohort in Severe asymptomatic aortic stenosis with normal ejection fraction (n=79). Left ventricular global longitudinal strain (GLS) was evaluated on Cardiac death and aortic valve replacement driven by symptom development (HR 1.14, 95% CI 1.01-1.28, p=0.037). Left ventricular global longitudinal strain predicted cardiac death and symptom-driven aortic valve replacement in severe asymptomatic aortic stenosis (HR 1.14; 95% CI 1.01-1.28; P=0.037).

synapsesocial.com/papers/6a208e80f14cd0624eb41b2f https://doi.org/10.1161/circimaging.112.977348

Topics

Echocardiography

View Full Paper

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September 25, 2012Circulation Cardiovascular ImagingOpen Access

Association of Myocardial Deformation With Outcome in Asymptomatic Aortic Stenosis With Normal Ejection Fraction

View Full Paper

Ask AI

Bookmark

Key result

Left ventricular global longitudinal strain predicted cardiac death and symptom-driven aortic valve replacement in severe asymptomatic aortic stenosis (HR 1.14; 95% CI 1.01-1.28; P=0.037).

Why the study?

Does left ventricular global longitudinal strain predict cardiac death and symptom-driven aortic valve replacement in patients with severe asymptomatic aortic stenosis?

Population

79 patients with severe asymptomatic aortic stenosis

Design

Cohort

Follow-up

23 ± 20 months

Authors

TYTeerapat YingchoncharoenRamathibodi Hospital CGConrad GibbyRocky Mountain University of Health Professions LRL. Leonardo RodriguezCardiac Imaging

Discussion

Member takes

Overview

May support GLS for risk stratification in asymptomatic severe AS; hypothesis-generating pending prospective validation.

Key Points

To determine if global longitudinal strain (GLS) can guide risk assessment in asymptomatic aortic stenosis patients.
Prospectively followed 79 patients with asymptomatic severe aortic stenosis.
Measured global longitudinal strain and conducted standard echocardiography.
Utilized multivariable Cox regression to analyze associations with cardiac death and AV replacement.
3 patients experienced cardiac death, and 49 underwent AV replacement over a mean follow-up of 23 months.
GLS predicted outcomes with a hazard ratio of 1.14 (95% CI, 1.01-1.28; P=0.037).
A mean absolute GLS <15% indicated significantly higher mortality, enhancing prognostic value beyond other risk metrics.

Study Design

Type

Cohort (n=79)

Structured PICO

Does left ventricular global longitudinal strain predict cardiac death and symptom-driven aortic valve replacement in patients with severe asymptomatic aortic stenosis?

Population

79 patients with severe asymptomatic aortic stenosis and normal ejection fraction, followed for a mean of 23 months.

Exposure

Left ventricular global longitudinal strain (GLS) assessment via speckle strain echocardiography

Outcome

Composite of cardiac death and aortic valve replacement driven by symptom developmentcomposite

Main Result

Hazard Ratio: 1.14 (95% CI 1.01–1.28)

p-value: p=0.037

Global longitudinal strain provides incremental prognostic value for predicting cardiac death and symptom-driven aortic valve replacement in patients with severe asymptomatic aortic stenosis.

Cite This Study

synapsesocial.com/papers/6a208e80f14cd0624eb41b2f https://doi.org/10.1161/circimaging.112.977348

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Topics

Echocardiography

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