Key result
Administration of bis-diamine to pregnant rats induced hypoplasia or aplasia of the aorticopulmonary septum and 6th aortic arch artery, resulting in various types of persistent truncus arteriosus.
Bis-diamine administration in pregnant rats induces various types of persistent truncus arteriosus in fetuses by causing hypoplasia or aplasia of the aorticopulmonary septum and 6th aortic arch artery.
Provides rat model for persistent truncus arteriosus; leaves open translation to human congenital heart disease mechanisms.
The influence of bis‐diamine on truncoconal septation was studied by the administration of 200 mg of this drug to pregnant Donryu‐strain rats on day 10 of gestation. Fetuses were removed at nine time periods from day 11 to 15. Some hearts were observed under a scanning electron microscope; others were serially sectioned and observed by light microscopy. In the treated group, the aorticopulmonary septum and the 6th aortic arch artery were hypoplastic or aplastic. Truncal swellings and conal ridges showed hypoplasia and failure to fuse. Various types of persistent truncus arteriosus were found in association with the degree of development of the 6th aortic arch artery and the aorticopulmonary septum. Fused 6th aortic arch arteries corresponded to Collett and Edwards' persistent truncus arteriosus type II, and non‐fused arteries to type III. Aplastic arteries belonged to type IV or were unclassifiable.
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Okishima et al. (1986) studied Persistent truncus arteriosus. Bis-diamine was evaluated on Truncoconal septation and development of persistent truncus arteriosus. Administration of bis-diamine to pregnant rats induced hypoplasia or aplasia of the aorticopulmonary septum and 6th aortic arch artery, resulting in various types of persistent truncus arteriosus.
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