Key result
Idiopathic skeletal deformities were associated with distinct environmental factors, such as talipes equinovarus with antepartum haemorrhage and maternal hypertension, compared to normal controls.
Case-Control (n=857)
No
Idiopathic skeletal deformities share a likely multifactorial genetic background but are associated with distinct environmental and antenatal factors.
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Associations with antepartum haemorrhage and maternal hypertension should not yet change practice; leaves open causal roles and need for prospective validation in multifactorial etiology.
Wynne-Davies et al. (1982) conducted a case-control in Idiopathic skeletal deformities (talipes equinovarus, calcaneovalgus, metatarsus varus, congenital dislocation of the hip, infantile idiopathic scoliosis) (n=857). Antenatal and environmental factors (e.g., maternal hypertension, breech presentation) vs. Normal infants (control group) was evaluated on Association with antenatal and environmental factors. Idiopathic skeletal deformities were associated with distinct environmental factors, such as talipes equinovarus with antepartum haemorrhage and maternal hypertension, compared to normal controls.
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