What question did this study set out to answer?

To assess the in vitro and in vivo antibacterial spectrum, target affinity, and therapeutic efficacy of the novel cephalosporin cefmenoxime.

January 1, 1981Antimicrobial Agents and ChemotherapyOpen Access

Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities

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Authors

KTKANJI TSUCHIYAToho University MKMasahiro KondoNihon University MKMakoto KidaMatsumoto Livestock Hygiene Service Center

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Implication

Preclinical evaluation reveals potent broad-spectrum antimicrobial activity of cefmenoxime in vitro and in mice, indicating therapeutic promise for severe infections.

Key Points

To assess the in vitro and in vivo antibacterial spectrum, target affinity, and therapeutic efficacy of the novel cephalosporin cefmenoxime.
Tested in vitro antibacterial activity against gram-positive and gram-negative pathogens across varying growth media, pH levels, and inoculum sizes.
Measured binding affinity to Escherichia coli penicillin-binding proteins (PBPs) and examined cellular morphological changes.
Evaluated in vivo protection in mice following intraperitoneal bacterial challenge and specific respiratory (Klebsiella pneumoniae) and urinary tract (Proteus mirabilis) infection models.
Cefmenoxime demonstrated 10- to 1,000-fold higher in vitro activity than comparator cephalosporins against Streptococcus pyogenes, Haemophilus influenzae, and Enterobacteriaceae species.
Activity against Pseudomonas aeruginosa was two- to four-fold greater than sulbenicillin and carbenicillin, though lower than cefsulodin.
The compound bound preferentially to PBP-3 and PBP-1 in Escherichia coli, inducing filamentous cell formation, and conferred high therapeutic protection in mouse systemic, lung, and urinary infection models.

Cite This Study

TSUCHIYA et al. (1981) studied this question.

synapsesocial.com/papers/6a993c29d2b4da1de4bd548b https://doi.org/10.1128/aac.19.1.56

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Implication

Preclinical evaluation reveals potent broad-spectrum antimicrobial activity of cefmenoxime in vitro and in mice, indicating therapeutic promise for severe infections.

Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities

Discussion

Member takes

Implication

Key Points

Cite This Study

Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities

Discussion

Member takes

Implication

Key Points

Cite This Study

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