Key result
SARS-CoV-2 is evolving toward attenuation and genetic degradation driven by host-initiated RNA editing and immune evasion, resulting in increased upper airway tropism and enhanced transmissibility.
SARS-CoV-2 is undergoing degenerative evolution and attenuation, resulting in variants with higher transmissibility but reduced lower respiratory tract virulence.
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May support milder future variants; hypothesis-generating and should not yet alter surveillance or management strategies.
Yingguang Liu (2023) conducted a review in COVID-19. SARS-CoV-2 evolution was evaluated. SARS-CoV-2 is evolving toward attenuation and genetic degradation driven by host-initiated RNA editing and immune evasion, resulting in increased upper airway tropism and enhanced transmissibility.
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