Key result
Normal spontaneous delivery was associated with significantly higher maternal plasma hANP concentrations (38.0 fmol/ml) compared to 36 weeks of normal pregnancy (16.8 fmol/ml).
Why the study?
Does the mode of delivery (vaginal vs. cesarean) affect plasma concentrations of human atrial natriuretic peptide (hANP)?
Observational (n=63)
Does the mode of delivery (vaginal vs. cesarean) affect plasma concentrations of human atrial natriuretic peptide (hANP)?
Vaginal delivery, but not elective cesarean section, is associated with significantly increased maternal and fetal plasma concentrations of atrial natriuretic peptide, likely due to the physical stress of labor.
Answers are grounded in this paper and cite their sources.
Vaginal delivery linked to higher maternal hANP; leaves open whether delivery mode affects peptide levels or outcomes.
The change in plasma concentration of atrial natriuretic peptide (hANP) at delivery was examined by measuring the concentrations of hANP in plasma samples from 21 subjects after 36 weeks of normal pregnancy, 22 subjects after normal spontaneous delivery and 20 subjects after elective cesarean section. The maternal plasma concentration of hANP after normal delivery (38.0 +/- 8.2 fmol/ml, mean +/- S.E.M.) was significantly higher than that after 36 weeks of normal pregnancy (16.8 +/- 2.3 fmol/ml), but its concentration after cesarean section was not different from that after 36 weeks of pregnancy. After normal delivery, the plasma concentration of hANP in the umbilical artery (66.9 +/- 11.8 fmol/ml) was also significantly higher than that in the umbilical vein (35.1 +/- 7.3 fmol/ml). In contrast, after elective cesarean section, the hANP levels in the umbilical artery and vein were not significantly different. These results suggest that hANP secretion into the maternal and fetal circulation may be stimulated by the dynamic movement of the mother in labour and the stress of the fetus at delivery, respectively.
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Okamoto et al. (1989) conducted an observational in Pregnancy (n=63). Normal spontaneous delivery vs. 36 weeks of normal pregnancy and elective cesarean section was evaluated on Maternal plasma concentration of hANP. Normal spontaneous delivery was associated with significantly higher maternal plasma hANP concentrations (38.0 fmol/ml) compared to 36 weeks of normal pregnancy (16.8 fmol/ml).
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