Key result
Closed mitral valvulotomy was associated with a lower incidence of late arterial emboli compared to unoperated management in patients with mitral stenosis (1.0% vs 3.7% per patient-year).
Why the study?
Does closed mitral valvulotomy reduce the incidence of late arterial emboli in patients with mitral stenosis compared to unoperated patients?
Cohort (n=526)
Does closed mitral valvulotomy reduce the incidence of late arterial emboli in patients with mitral stenosis compared to unoperated patients?
Closed mitral valvulotomy provides significant protective value against late systemic arterial embolism in patients with mitral stenosis, especially those with pre-operative atrial fibrillation.
Answers are grounded in this paper and cite their sources.
May support valvulotomy consideration in mitral stenosis with AF; leaves open randomized confirmation of emboli benefit.
During an average period of follow-up of 6 years, 255 patients subjected to closed mitral valvulotomy had an incidence of late arterial emboli of 1.0% per patient-year. In an unoperated series of 271 patients with mitral stenosis the incidence was 3.7% per patient-year. The significant protective value of mitral valvulotomy against late systemic embolism was particularly evident in patients with pre-operative atrial fibrillation. In subjects with pre-operative arterial emboli the rate of late embolism was 3.0% per patient-year, and it is suggested that long-term anticoagulant therapy is considered in this group of patients.
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Olesen et al. (1972) conducted a cohort in Mitral stenosis (n=526). Closed mitral valvulotomy vs. Unoperated was evaluated on Late arterial emboli. Closed mitral valvulotomy was associated with a lower incidence of late arterial emboli compared to unoperated management in patients with mitral stenosis (1.0% vs 3.7% per patient-year).
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