Why the study?
Does mitral valve replacement with a pericardial xenograft without long-term anticoagulation result in a low incidence of systemic embolism?
Population
461 patients undergoing mitral valve replacement with a pericardial xenograft.
Design
Cohort
Authors
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Should not yet change anticoagulation practice after pericardial mitral replacement; hypothesis-generating and requires randomized confirmation.
Does mitral valve replacement with a pericardial xenograft without long-term anticoagulation result in a low incidence of systemic embolism?
Mitral valve replacement with a pericardial xenograft without long-term anticoagulation is associated with a very low rate of systemic embolism (0.55% per annum), comparing favorably to historical rates for porcine heterografts.
Silverton et al. (1984) studied this question.
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