Key result
Chronic renal failure and hemodialysis were associated with significantly increased oxidative stress, evidenced by elevated malondialdehyde levels (5.62 vs 0.70 in controls, p<0.001) and reduced antioxidant markers.
Why the study?
Oxidative stress markers are elevated in CKD patients and recognized as contributing to CKD pathology, but comparisons across stages of renal failure and hemodialysis are needed.
Does hemodialysis affect oxidant and anti-oxidant parameters in patients with chronic renal failure compared to healthy controls?
Cross-Sectional (n=200)
No
Does hemodialysis affect oxidant and anti-oxidant parameters in patients with chronic renal failure compared to healthy controls?
Hemodialysis alters oxidative stress markers in chronic renal failure patients, highlighting a potential mechanism for increased cardiovascular risk in this population.
Chronic kidney disease (CKD) is featured by a progressive decline of kidney function and is mainly caused by chronic diseases such as diabetes mellitus and hypertension. CKD is a complex disease due to cardiovascular complications and high morbidity; however, there is no single treatment to improve kidney function in CKD patients. Since biological markers representing oxidative stress are significantly elevated in CKD patients, oxidative stress is receiving attention as a contributing factor to CKD pathology. Aim of our study is comparison of oxidant and anti oxidant parameters in chronic renal failure, Hemodialysis (pre and post) and control subjects. Materials and Methods: The present study was conducted on a patient group comprising of 50 patients diagnosed with CRF, 50 were pre hemodialysis, 50 were post hemodialysis (MHD). This patient group was compared to a healthy group including 100 controls. All the study participants were admitted in the department of Medicine [Nephrology department] at “Rajiv Gandhi Institute Of Medical Sciences”, Kadapa. Andhra Pradesh. India. Study Period : July 2020 to December 2020 ,The obtained serum samples were used for biochemical analysis for estimating MDA, vitamin A and Glutathione Peroxidase (GPx).
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Rao et al. (2022) conducted a cross-sectional in Chronic Renal Failure (n=200). Chronic Renal Failure and Hemodialysis vs. Healthy controls was evaluated on Plasma malondialdehyde (MDA) levels (p=<0.001). Chronic renal failure and hemodialysis were associated with significantly increased oxidative stress, evidenced by elevated malondialdehyde levels (5.62 vs 0.70 in controls, p<0.001) and reduced antioxidant markers.
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