Key result
Apelin peptides play important roles in the pathogenesis of diabetic complications, and diabetics may exhibit apelin resistance, suggesting potential clinical applications for apelin analogues.
Apelin and its analogue peptides may have potential clinical applications in treating diabetic complications, potentially addressing a proposed state of apelin resistance.
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Apelin analogues merit investigation in diabetic complications; leaves open clinical translation pending prospective trials.
Diabetes is a metabolic disorder with multiple complications, including cardiomyopathy, retinopathy, nephropathy and neuropathy. Diabetic complications are the major cause of disability and death in diabetic patients. Apelin, a recently identified adipokine peptide, has been found to play important roles in diabetic complications. Here we summarize the current knowledge on the role of apelin in the pathogenesis of different diabetic complications. We also propose that similar to insulin resistance or leptin resistance, diabetics may also show apelin resistance. Potential clinical application of apelin and its analogue peptides in treating diabetic complications is discussed.
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Chen et al. (2017) conducted a review in Diabetic complications. Apelin peptides was evaluated. Apelin peptides play important roles in the pathogenesis of diabetic complications, and diabetics may exhibit apelin resistance, suggesting potential clinical applications for apelin analogues.
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